Allan D Struthers Selected Research

Allopurinol (Remid)

1/2021	A Randomized, Controlled Trial of the Effect of Allopurinol on Left Ventricular Mass Index in Hemodialysis Patients.
1/2020	Allopurinol in Patients with Pulmonary Hypertension Associated with Chronic Lung Disease.
12/2019	Allopurinol treatment adversely impacts left ventricular mass regression in patients with well-controlled hypertension.
2/2018	The APEX trial: Effects of allopurinol on exercise capacity, coronary and peripheral endothelial function, and natriuretic peptides in patients with cardiac syndrome X.
1/2016	Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study.
1/2016	A Randomized Controlled Trial of Allopurinol in Patients With Peripheral Arterial Disease.
12/2013	Allopurinol reduces left ventricular mass in patients with type 2 diabetes and left ventricular hypertrophy.
3/2013	High-dose allopurinol reduces left ventricular mass in patients with ischemic heart disease.
8/2011	Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris.
7/2011	Allopurinol benefits left ventricular mass and endothelial dysfunction in chronic kidney disease.

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Allan D Struthers Research Topics

Disease

44	Heart Failure 01/2021 - 01/2002
14	Hypertension (High Blood Pressure) 12/2019 - 09/2002
11	Cardiovascular Diseases (Cardiovascular Disease) 12/2019 - 07/2002
10	Left Ventricular Dysfunction 01/2020 - 07/2002
10	Fibrosis (Cirrhosis) 10/2016 - 01/2002
8	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2020 - 07/2002
7	Type 2 Diabetes Mellitus (MODY) 01/2021 - 10/2010
6	Myocardial Infarction 06/2017 - 09/2004
5	Chronic Obstructive Pulmonary Disease (COPD) 01/2020 - 01/2013
5	Heart Diseases (Heart Disease) 01/2016 - 07/2002
4	Sarcopenia 01/2022 - 01/2006
4	Myocardial Ischemia (Ischemic Heart Diseases) 01/2021 - 03/2011
4	Insulin Resistance 01/2020 - 11/2012
4	Inflammation (Inflammations) 01/2018 - 04/2007
4	Cardiac Sudden Death (Sudden Cardiac Arrest) 09/2004 - 11/2002
3	Chronic Renal Insufficiency 01/2021 - 07/2011
3	Body Weight (Weight, Body) 11/2020 - 11/2019
3	Pulmonary Hypertension 01/2020 - 04/2014
3	Hypertrophy 12/2019 - 11/2002
3	Coronary Artery Disease (Coronary Atherosclerosis) 11/2019 - 11/2007
3	Weight Loss (Weight Reduction) 10/2017 - 11/2012
3	Diabetes Mellitus 09/2017 - 10/2005
3	Acute Coronary Syndrome 10/2015 - 02/2002
3	Systolic Heart Failure 11/2012 - 05/2004
3	Chest Pain (Chest Pains) 08/2011 - 01/2009
3	Death (Near-Death Experience) 10/2008 - 01/2002
2	Essential Hypertension 12/2019 - 01/2015
2	Microvascular Angina (Cardiac Syndrome X) 02/2018 - 01/2009
2	Pain (Aches) 01/2016 - 01/2016
2	Gout 01/2016 - 01/2009
2	Isolated Systolic Hypertension 08/2014 - 10/2013
2	Necrosis 08/2013 - 09/2012
2	Stable Angina 03/2013 - 06/2010
2	Aortic Valve Stenosis (Aortic Stenosis) 01/2013 - 08/2011
2	Hyperuricemia 02/2012 - 01/2003
2	Birth Weight (Birth Weights) 09/2010 - 11/2008
2	Chronic Disease (Chronic Diseases) 09/2010 - 10/2007
2	Fetal Growth Retardation (Intrauterine Growth Retardation) 09/2010 - 10/2007
2	Pre-Eclampsia (Preeclampsia) 08/2010 - 10/2007
2	Respiratory Sounds (Crackle) 05/2010 - 09/2004
2	Muscular Diseases (Myopathy) 03/2010 - 05/2003
2	Stroke (Strokes) 10/2008 - 01/2008
2	Hyperaldosteronism (Conn Syndrome) 05/2007 - 01/2002
2	Atrial Fibrillation 07/2005 - 07/2002
1	Prediabetic State (Prediabetes) 01/2021
1	Vascular Calcification 10/2020
1	Lung Diseases (Lung Disease) 01/2020
1	Ventricular Remodeling 01/2020

Drug/Important Bio-Agent (IBA)

18	AldosteroneIBA 07/2013 - 01/2002
14	Allopurinol (Remid)FDA LinkGeneric 01/2021 - 07/2002
13	Brain Natriuretic Peptide (Natrecor)FDA Link 02/2018 - 02/2002
13	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2018 - 09/2002
12	Spironolactone (Aldactone)FDA LinkGeneric 01/2016 - 01/2002
10	Biomarkers (Surrogate Marker)IBA 11/2019 - 03/2011
9	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2018 - 08/2004
8	Xanthine OxidaseIBA 01/2020 - 07/2002
7	Vitamin D FDA LinkGeneric 01/2018 - 10/2009
6	Uric Acid (Urate)IBA 11/2020 - 01/2003
6	C-Reactive ProteinIBA 01/2020 - 04/2007
5	25-hydroxyvitamin DIBA 05/2015 - 03/2010
4	DiureticsIBA 11/2020 - 05/2007
4	Natriuretic PeptidesIBA 02/2018 - 07/2002
4	Cholecalciferol (Vitamin D3)FDA Link 08/2014 - 08/2013
4	Mineralocorticoid Receptor AntagonistsIBA 11/2012 - 01/2004
4	ReninIBA 01/2010 - 01/2002
4	Eplerenone (Inspra)FDA LinkGeneric 12/2007 - 11/2002
3	Perindopril FDA LinkGeneric 01/2022 - 10/2007
3	dapagliflozinIBA 01/2021 - 01/2020
3	Sodium-Glucose Transporter 2 InhibitorsIBA 11/2020 - 07/2016
3	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA 11/2020 - 05/2004
3	Metformin (Glucophage)FDA LinkGeneric 11/2019 - 10/2010
3	CholesterolIBA 09/2017 - 08/2013
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 05/2016 - 06/2014
3	Pharmaceutical PreparationsIBA 03/2013 - 09/2002
3	PotassiumIBA 05/2010 - 01/2004
3	Atrial Natriuretic Factor (ANF)IBA 07/2005 - 02/2003
3	ElectrolytesIBA 09/2004 - 11/2002
2	Leucine (L-Leucine)FDA Link 01/2022 - 01/2018
2	empagliflozinIBA 01/2021 - 11/2020
2	Proteins (Proteins, Gene)FDA Link 10/2020 - 11/2011
2	GadoliniumIBA 06/2017 - 10/2016
2	Oxygen (Dioxygen)IBA 11/2015 - 01/2013
2	Ezetimibe (Zetia)FDA Link 10/2015 - 06/2014
2	Antihypertensive Agents (Antihypertensives)IBA 01/2015 - 10/2012
2	E-SelectinIBA 08/2013 - 09/2012
2	Insulin (Novolin)FDA Link 11/2012 - 10/2012
2	CytokinesIBA 09/2012 - 05/2003
2	Biological ProductsIBA 09/2012 - 10/2002
2	C-Type Natriuretic Peptide (Peptide, C-Type Natriuretic)IBA 10/2009 - 02/2003
2	Superoxides (Superoxide)IBA 01/2009 - 03/2004
2	Peptides (Polypeptides)IBA 11/2007 - 10/2002
2	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 01/2005 - 03/2004
2	Losartan (Cozaar)FDA LinkGeneric 07/2004 - 06/2004
2	Angiotensin IIIBA 03/2002 - 01/2002
1	SugarsIBA 01/2021
1	Vitamin K FDA Link 10/2020
1	Thiobarbituric Acid Reactive SubstancesIBA 11/2019
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2018
1	MicroRNAs (MicroRNA)IBA 01/2018

Therapy/Procedure

20	Therapeutics 10/2020 - 03/2002